Collagen-Type Classification
| TYPE | SUBUNITS alpha-POLY- PEPTIDES |
COMPOSITION | STRUCTURE / GROUP |
TISSUE DISTRIBUTION - not comprehensive - |
GENE SYMBOL |
GENOME LOCATION (HUMAN) |
| I | α1(I) α2(I) |
[α1(I)]2α2(I) [α1(I)]3 |
Fibrillar | skin, bone, tendon, ligament, cornea, placenta, liver, muscle, uterus, amnion, lung |
COL1A1 COL1A2 |
17q21.34-q22 7q22.1 |
| II | α1(II) | [α1(II)]3 | Fibrillar | cartilage, annulus fibrosus of intervertebral disc, vitreous humor |
COL2A1 | 12q13.1-q13.2 |
| III | α1(III) | [α1(III)]3 | Fibrillar | coexpressed with collagen I, in vasculature and skin, fetal dermis, placenta, synovia, liver |
COL3A1 | 2q32 |
| IV | α1(IV) α2(IV) α3(IV) α4(IV) α5(IV) α6(IV) |
α1(VI)]2α2(IV) α3(IV)]α4(IV)α5(IV) [α5(IV)]2α6(IV) |
3D-Network | most basement membranes, glomerular and alveolar BM, lens capsule, placenta, aorta, glomerulus of kidney, EHS sarcoma |
COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 |
13q34 13q34 2q36-q37 2q35-q37 Xq22 Xq22 |
| V | α1(V) α2(V) α3(V) α4(V) |
[α1(V)]2α2(V) [α1(V)]3 α1(V)α2(V)α3(V) |
Fibrillar | coexpressed with collagen I in lung, corneal stroma, bone, nervous system, Placenta, amnion, skin, tendon, synovia, liver, muscle, lung cultured chinese hamster cells |
COL5A1 COL5A2 COL5A3 |
9q34.2-q34.3 2q14-q32 19p13.2 |
| VI | α1(VI) α2(VI) α3(VI) α5(VI) α6(VI) |
α1(VI)α2(VI)α3(VI) | Microfibril | wide tissue distribution, not bone, placenta, liver, uterus, aorta, fibroblasts of ligamentum nuchae |
COL6A1 COL6A2 COL6A3 COL6A5 COL6A6 |
21q22.3 21q22.3 2q37 3q22.1 3q22.1 |
| VII | α1(VII) | [α1(VII)]3 | Anchoring Fibril | squamous epithelium BM zone, placenta, dermal fibroblasts |
COL7A1 | 3p21.1 |
| VIII | α1(VIII) α2(VIII) |
[α1(VIII)]2α2(VIII) [α1(VIII)]3 [α2(VIII)]3 |
Hexagonal Lattice | many tissues, descement's membrane of cornea, cultured bovine endothelial cells |
COL8A1 COL8A2 |
3q12-q13 1p34.2 |
| IX | α1(IX) α2(IX) α3(IX) |
α1(IX)α2(IX)α3(IX) | FACIT | associated with type II fibrils in cartilage and cornea, human fetus, hyaline cartilage(mammalian), cultured chondrocytes, animal embryo, eye vitreous humor |
COL9A1 COL9A2 COL9A3 |
6q12-q14 1p32.2-p33 20q13.3 |
| X | α1(IX) | [α1(X]3 | Hexagonal Lattice | hypertrophic cartilage, chick embryo chondrocytes |
COL10A1 | 6q21-q22 |
| XI | α1(XI) α2(XI) α3(XI) |
α1(XI)α2(XI)α3(XI) | Fibrillar | coexpressed with collagen II, cartilage, annulus fibrosus, nucleus pulposus(fetal) |
COL11A1 COL11A2 COL11A2P |
1p21 6p21.3 6p21 |
| XII | α1(XII) | [α1(XII]3 | FACIT | associated with type I fibrils in perchondrium, ligament, tendon, embryonic tissue |
COL12A1 | 6q12-q13 |
| XIII | α1(XIII) | ?(Homotrimer)? | Transmembrane | many tissues at a low level human fetal tissue, lens capsule BM |
COL13A1 | 10q22 |
| XIV | α1(XIV) | [α1(XIV]3 | FACIT | associated with type I fibrils in many tissues |
COL14A1 | 8q23 |
| XV | α1(XV) | ?(Homotrimer)? | Multiplexin | many BM zones | COL15A1 | 9q21-q22 |
| XVI | α1(XVI) | ?(Homotrimer)? | FACIT | associated with type II fibrils in hyaline cartilage and with microfibrils in skin |
COL16A1 | 1p34-p35 |
| XVII | α1(XVII) | [α1(XVII]3 | Transmembrane | skin and intestinal epithelia | COL17A1 | 10q24.3 |
| XVIII | α1(XVIII) | ?(Homotrimer)? | Multiplexin | endothelial and epithelial BM zones | COL18A1 | 21q22.3 |
| XIX | α1(XIX) | ?(Homotrimer)? | FACIT-like | rare BM zones, in developing muscle | COL19A1 | 6q12-q13 |
| XX | α1(XX) | ?(Homotrimer)? | FACIT | associated with type I fibrils in sternal cartilage, cornea, tendon |
COL20A1 | 20q13.33 |
| XXI | α1(XXI) | ?(Homotrimer)? | FACIT | associated with type I fibrils in vessel walls |
COL21A1 | 6p11.2-p12.3 |
| XXII | α1(XXII) | ?(Homotrimer)? | FACIT-like | associated with microfibrils at tissue junctions |
COL22A1 | 8q24.23 |
| XXIII | α1(XXIII) | ?(Homotrimer)? | Transmembrane | heart, lung and brain, metastatic cells | COL23A1 | 5q35.3 |
| XXIV | α1(XXIV) | ?(Homotrimer)? | Fibrillar | coexpressed with collagen I in bone and cornea |
COL24A1 | 1p22.3 |
| XXV CLAC-P |
α1(XXV) | ?(Homotrimer)? | Transmembrane | neurons | COL25A1 | 4q25 |
| (XXVI) = EMID2 |
α1(XXVI) | ?(Homotrimer)? | FACIT-like | testis and ovary | COL26A1(?) | (7q22.1) |
| XXVII | α1(XXVII) | ?(Homotrimer)? | Fibrillar | coexpressed with collagen II in cartilage and epithelia |
COL27A1 | 9q33.1 |
| XXVIII | α1(XXVIII) | ?(Homotrimer)? | Fibrillar | peripheral nerves | COL28A1 | 7p21.3 |
| XXIX | ||||||
Abbreviations:
FACIT = Fibril associated collagens with interrupted tripelhelices
MULTIPLEXIN = Multiple triple helix and interruptions
CLAC-P = Collagen-like Alzheier amyloid component precursor
BM = Basement Membrane